Belgium booked its place at next year’s World Cup with a 3-1 win over Estonia in their qualifying group on Saturday.
With just one match left to play in Group E, top-ranked Belgium remained unbeaten and has an unassailable five-point lead over second-place Wales, which defeated Belarus 5-1 in Cardiff with Gareth Bale making his 100th appearance for Wales.
Despite the absence of several key players, including Romelu Lukaku, Belgian attacks kept coming at King Baudouin stadium and the Red Devils should have won by a bigger margin if not for their profligacy in front of goal.
Christian Benteke, who replaced Lukaku up front, put the hosts in front early and Yannick Carrasco made it 2-0 after the interval. Belgium briefly lost its focus in the last 20 minutes, allowing Estonia to come back in the match through a goal from substitute Erik Sorga before Thorgan Hazard restored a two-goal lead.
Wales is guaranteed a World Cup playoff spot through its Nations League results.
The 12-team playoffs will decide who joins the 10 European qualifying group winners at the tournament. The playoff draw will include runners-up in the 10 groups plus two group winners from the UEFA Nations League.
One more point will be enough for Wales in its final qualifier against Belgium on Tuesday to secure second place in the group and home advantage in their semifinal playoff.