Jose Mourinho and AS Roma were 3 goals down at halftime and went on to lose by that scoreline at the Stadio Olympico to defending champions Inter Milan no thanks to goals from Hakan Calhanoglu, Denzel Dumfries and Edin Dzeko.
Juventus kept things simple at the Allianz stadium securing a 2-0 victory over Genoa with goals from Juan Cuadrado and Paulo Dybala.
Elsewhere at the San Siro Stadium, two early goals from Frank Kessie and Saelemaekers proved enough to hand the Rossoneri a 2-0 victory over new comers Salernitana.
Napoli relinquished their lead on top the log following a 3-2 home loss to Atalanta.
Stadio Olympico produced another classic match as Lazio and Udinese put 4 goals past each other in a thrilling 4-4 draw.
AC Milan are now top of the log with 38 points but are closely followed by neighbors Inter Milan who are placed second with 37. Napoli now occupy the third spot with 36 points while Atalanta have moved closer with 34 points in 4th. Juventus are 7 points adrift in 5th with 27 points.