Victor Osimhen scored his 17th goal of the season as Napoli go 16 points clear at the top of the Seria A table.
Osimhen is now 5 goals clear at the top of the top scorer table with the closest person being Ademola Lookman with 12 goals.
A dangerous ball into the box was headed away by the Cremonese defender, but Kvaratskhelia did enough to keep the ball in play before driving into the box and firing a low curling shot into the box.
Five minutes after the hour mark, two series of headers from a corner fell kindly for Osimhen to tap into the net and double their advantage.
Elmas was subbed on in the second half and found the back of the net before the 80th minute, when Di Lorenzo set him up in the box for a one v one.
Napoli are now on a nine straight home league wins, their longest run since 1989-90, which is the last time they won the league.
With Osimhen’s 17goals in 18 matches, he seems destined for The Capocannoniere award.