Zaidu Sanusi puts in a good shift in defense for FC Porto but his effort was setback by a brilliant Romelu Lukaku late goal to give Inter a 1-0 lead in the tie.
Inter are likely to feel more assured about progressing to the quarter-finals and making a long-awaited comeback.
The match was notable for the goalkeeping skills of both André Onana and Diogo Costa, who made several important saves.
It seemed like neither team would score until Porto’s Otávio was given a red card for two bookings and Romelu Lukaku scored a decisive goal to send the San Siro stadium into a frenzy.
This season, Inter have been quietly impressive, having defeated the leading team in Serie A, Napoli. They are well-positioned to finish the job in Portugal.
Italian football is also on the rise, with Milan and Napoli also holding first-leg leads, making it the first time that three Italian teams have been in such a strong position to reach the last eight.
After the disappointment of the Azzurri’s absence from the World Cup and the chaos at Juventus, could this be a chance for Italian football to restore some pride on the global stage?
Meanwhile, Super Eagles left back, Zaidu Sanusi made five tackles and eight clearances and almost got on the scoresheet but was denied by Onana.